The client-side editor will call the named JavaScript function on the page whenever the modified flag changes. This allows the developer to take appropriate action, such as perhaps enabling and disabling a Save button on the page.

Set the property declaratively in the HtmlEditor tag:

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ModifiedChanged = "MyModifiedHandler"

Page JavaScript function:

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function MyModifiedHandler(editor, isModified)
{
    var saveButton = $get("SaveButton");
    saveButton.disabled = !isModified;
}